In the Name of Science: A History of Secret Programs, Medical Research, and Human Experimentation, Andrew Goliszek; November 15, 2003, St. Martin's Press, ISBN-13: 978-0312303563

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Unethical human experimentation in the

United States

This article is about U.S. medical experiments that are alleged to be unethical, non-consensual, or illegal. For the consensual, ethical, and legal use of human beings in medical research, see Human subject research.

Particularly in the 20th century, there have been numer¬ ous experiments performed on human test subjects in the United States that have been considered unethical, and were often performed illegally, without the knowledge, consent, or informed consent of the test subjects.

The experiments include: the deliberate infection of peo¬ ple with deadly or debilitating diseases, exposure of peo¬ ple to biological and chemical weapons, human radiation experiments, injection of people with toxic and radioac¬ tive chemicals, surgical experiments, interrogation and torture experiments, tests involving mind-altering sub¬ stances, and a wide variety of others. Many of these tests were performed on children, 111 the sick, and mentally dis¬ abled individuals, often under the guise of “medical treat¬ ment”. In many of the studies, a large portion of the sub¬ jects were poor, racial minorities or prisoners.

Funding for many of the experiments was provided by United States government, especially the United States military. Central Intelligence Agency, or private corpo¬ rations involved with military activities. The human re¬ search programs were usually highly secretive, and in many cases information about them was not released until many years after the studies had been performed.

The ethical, professional, and legal implications of this in the United States medical and scientific community were quite significant, and led to many institutions and poli¬ cies that attempted to ensure that future human subject research in the United States would be ethical and legal. Public outrage in the late 20th century over the discovery of government experiments on human subjects led to nu¬ merous congressional investigations and hearings, includ¬ ing the Church Committee and Rockefeller Commission, both of 1975 and the 1994 Advisory Committee on Hu¬ man Radiation Experiments, among others.

1 Surgical experiments

Throughout the 1840s, J. Marion Sims, who is often re¬ ferred to as “the father of gynecology", performed sur¬ gical experiments on enslaved African women, without

anaesthesia. The women—one of whom was operated on 30 times—regularly died from infections resulting from the experiments. 121 In order to test one of his the¬ ories about the causes of trismus in infants, Sims per¬ formed experiments where he used a shoemaker’s awl to move around the skull bones of the babies of enslaved women. 131141 He also addicted the women in his surgical experiments to morphine, only providing the drugs af¬ ter surgery was already complete, in order to make them more compliant. 151

In 1874, Mary Rafferty, an Irish servant woman, came to Dr. Roberts Bartholow of the Good Samaritan Hos¬ pital in Cincinnati for treatment of her cancer. Seeing a research opportunity, he cut open her head, and inserted needle electrodes into her exposed brain matter. 161 He de¬ scribed the experiment as follows:

When the needle entered the brain sub¬ stance, she complained of acute pain in the neck. In order to develop more decided reactions, the strength of the current was increased ... her countenance exhibited great distress, and she began to cry. Very soon, the left hand was extended as if in the act of taking hold of some object in front of her; the arm presently was agitated with clonic spasm; her eyes became fixed, with pupils widely dilated; lips were blue, and she frothed at the mouth; her breathing became stertorous; she lost con¬ sciousness and was violently convulsed on the left side. The convulsion lasted five minutes, and was succeeded by a coma. She returned to consciousness in twenty minutes from the beginning of the attack, and complained of some weakness and vertigo.

—Dr. Bartholow’s research report 161

In 1896, Dr. Arthur Wentworth performed spinal taps on 29 young children, without the knowledge or consent of their parents, at the Children’s Hospital in Boston, Massachusetts to discover whether doing so would be harmful. 171

From 1913 to 1951, Dr. Leo Stanley, chief surgeon at the San Quentin Prison, performed a wide variety of experi¬ ments on hundreds of prisoners at San Quentin. Many of the experiments involved testicular implants, where Stan¬ ley would take the testicles out of executed prisoners and

1

2

2 PATHOGENS, DISEASE, AND BIOLOGICAL WARFARE AGENTS

surgically implant them into living prisoners. In other ex¬ periments, he attempted to implant the testicles of rams, goats, and boars into living prisoners. Stanley also per¬ formed various eugenics experiments, and forced steril¬ izations on San Quentin prisoners. 181 Stanley believed that his experiments would rejuvenate old men, control crime (which he believed had biological causes), and prevent the “unfit” from reproducing. 181191

2 Pathogens, disease, and biologi¬ cal warfare agents

A subject of the Tuskegee syphilis experiment has his blood drawn, c. 1953

2.1 Late 19th century

In the 1880s, in Hawaii, a California physician working at a hospital for lepers injected six girls under the age of 12 with syphilis. 171

In 1895, New York City pediatrician Henry Heiman intentionally infected two mentally disabled boys—one four-year-old and one sixteen-year old—with gonorrhea as part of a medical experiment. A review of the medical literature of the late 19th and early 20th centuries found more than 40 reports of experimental infections with gon¬ orrheal culture, including some where gonorrheal organ¬ isms were applied to the eyes of sick children. 171110,1111

U.S Army doctors in the Philippines infected five pris¬ oners with bubonic plague and induced beriberi in 29 prisoners; four of the test subjects died as a result. 11211131 In 1906, Professor Richard Strong of Harvard University intentionally infected 24 Filipino prisoners with cholera, which had somehow become contaminated with plague. He did this without the consent of the patients, and with¬ out informing them of what he was doing. All of the sub¬ jects became sick and 13 died. 11311141

2.2 Early 20th century

In 1908, three Philadelphia researchers infected dozens of children with tuberculin at the St. Vincent’s House or¬ phanage in Philadelphia, causing permanent blindness in some of the children and painful lesions and inflamma¬ tion of the eyes in many of the others. In the study they refer to the children as “material used”. 1 131

In 1909, F. C. Knowles released a study describing how he had deliberately infected two children in an orphan¬ age with Molluscum contagiosum after an outbreak in the orphanage, in order to study the disease. 171

In 1911, Dr. Hideyo Noguchi of the Rockefeller In¬ stitute for Medical Research injected 146 hospital pa¬ tients (some of whom were children) with syphilis. He was later sued by the parents of some of the child sub¬ jects, who allegedly contracted syphilis as a result of his experiments. [ 161

The Tuskegee syphilis experiment 1171 was a clinical study conducted between 1932 and 1972 in Tuskegee, Al¬ abama, by the U.S. Public Health Service. In the exper¬ iment, 400 impoverished black males who had syphilis were offered “treatment” by the researchers, who did not tell the test subjects that they had syphilis and did not give them treatment for the disease, but rather just studied them to chart the progress of the disease. By 1947, penicillin became available as treatment, but those running the study prevented study participants from re¬ ceiving treatment elsewhere, lying to them about their true condition, so that they could observe the effects of syphilis on the human body. By the end of the study in 1972, only 74 of the test subjects were alive. 28 of the original 399 men had died of syphilis, 100 were dead of related complications, 40 of their wives had been infected, and 19 of their children were born with congenital syphilis. The study was not shut down until 1972, when its existence was leaked to the press, forcing the researchers to stop in the face of a public outcry. 1181

2.3 1940s

In 1941, at the University of Michigan, virologists Thomas Francis, Jonas Salk and other researchers delib¬ erately infected patients at several Michigan mental insti¬ tutions with the influenza virus by spraying the virus into their nasal passages. 1191 Francis Payton Rous, based at the Rockefeller Institute and editor of the Journal of Experi¬ mental Medicine, wrote the following to Francis regarding the experiments:

“It may save you much trouble if you pub¬ lish your paper... elsewhere than in the Journal of Experimental Medicine. The Journal is un¬ der constant scrutiny by the anti-vivisectionists who would not hesitate to play up the fact that you used for your tests human beings of a state

2.4 1950s

3

institution. That the tests were wholly justified goes without saying.” 1201

Rous closely monitored the articles he published since the 1930s, when revival of the anti-vivisectionist movement raised pressure against certain human experimentation. 1211

In 1941 Dr. William C. Black inoculated with herpes a twelve-month-old baby “offered as a volunteer”. He submitted his research to The Journal of Experimental Medicine and it was rejected on ethical grounds. The edi¬ tor of the Journal of Experimental Medicine , Francis Pay- ton Rous, called the experiment “an abuse of power, an infringement of the rights of an individual, and not excus¬ able because the illness which followed had implications for science.” 122112311241 The study was later published in the Journal of Pediatrics} 2 ^

The Stateville Penitentiary was the site of a controlled study of the effects of malaria on the prisoners of Stateville Penitentiary near Joliet, Illinois beginning in the 1940s. The study was conducted by the Depart¬ ment of Medicine at the University of Chicago in con¬ junction with the United States Army and the State De¬ partment. At the Nuremberg trials, Nazi doctors cited the precedent of the malaria experiments as part of their defense. 12611271 The study continued at Stateville Peniten¬ tiary for 29 years. In related studies from 1944 to 1946, Dr. Alf Alving, a professor at the University of Chicago Medical School, purposely infected psychiatric patients at the Illinois State Hospital with malaria, so that he could test experimental treatments on them. 12 ’ 0

In a 1946 to 1948 study in Guatemala, U.S. researchers used prostitutes to infect prison inmates, insane asy¬ lum patients, and Guatemalan soldiers with syphilis and other sexually transmitted diseases, in order to test the effectiveness of penicillin in treating the STDs. They later tried infecting people with “direct inoculations made from syphilis bacteria poured into the men’s penises and on forearms and faces that were slightly abraded ... or in a few cases through spinal punctures”. Approximately 700 people were infected as part of the study (includ¬ ing orphan children). The study was sponsored by the Public Health Service, the National Institutes of Health and the Pan American Health Sanitary Bureau (now the World Health Organization's Pan American Health Or¬ ganization) and the Guatemalan government. The team was led by John Charles Cutler, who later participated in the Tuskegee syphilis experiments. Cutler chose to do the study in Guatemala because he would not have been permitted to do it in the United States. In 2010 when the research was revealed, the US officially apologized to Guatemala for the studies. 1291130113111321

2.4 1950s

In 1950, in order to conduct a simulation of a biologi¬ cal warfare attack, the U.S. Navy used airplanes to spray large quantities of the bacteria Serratia marcescens - considered harmless at this time - over the city of San Francisco. Numerous citizens contracted pneumonia¬ like illnesses, and at least one person died as a result. 133113411351136113711381 The family of the man who died sued the government for gross negligence, but a federal judge ruled in favor of the government in 1981. 1391 Ser¬ ratia tests were continued until at least 1969. 1401

Also in 1950, Dr. Joseph Stokes of the University of Pennsylvania deliberately infected 200 female prisoners with viral hepatitis. 1411

From the 1950s to 1972, mentally disabled children at the Willowbrook State School in Staten Island, New York were intentionally infected with viral hepatitis, for re¬ search whose purpose was to help discover a vaccine. 1421 From 1963 to 1966, Saul Krugman of New York Univer¬ sity promised the parents of mentally disabled children that their children would be enrolled into Willowbrook in exchange for signing a consent form for procedures that he claimed were “vaccinations.” In reality, the procedures involved deliberately infecting children with viral hepati¬ tis by feeding them an extract made from the feces of patients infected with the disease. 14311441

In 1952, Chester M. Southam, a Sloan-Kettering Institute researcher, injected live cancer cells into prisoners at the Ohio State Prison. Also at Sloan-Kettering, 300 healthy women were injected with live cancer cells without being told. The doctors stated that they knew at the time that it might cause cancer. 1451

In 1955, the CIA allegedly conducted a biological warfare experiment where they released whooping cough bacte¬ ria from boats outside of Tampa Bay, Florida, causing a whooping cough epidemic in the city, and killing at least 12 people. 146114711481 However, some have expressed im¬ probability and lack of evidence for this claim. 1491

During the 1950s the United States conducted a series of field tests using entomological weapons. Operation Big Itch, in 1954, was designed to test munitions loaded with uninfected fleas (Xenopsylla cheopis). In May 1955 over 300,000 yellow fever mosquitoes (Aedes aegypti) were dropped over parts of the U.S. state of Georgia to deter¬ mine if the air-dropped mosquitoes could survive to take meals from humans. The mosquito tests were known as Operation Big Buzz. The U.S. engaged in at least two other EW testing programs. Operation Drop Kick and Operation May Day.

2.5 1960s

In 1963, 22 elderly patients at the Jewish Chronic Disease Hospital in Brooklyn, New York were injected with live

4

5 HUMAN RADIATION EXPERIMENTS

cancer cells by Chester M. Southam, who in 1952 had done the same to prisoners at the Ohio State Prison, in order to “discover the secret of how healthy bodies fight the invasion of malignant cells”. The administration of the hospital attempted to cover the study up, but the New York medical licensing board ultimately placed Southam on probation for one year. Two years later, the American Cancer Society elected him as their Vice President. 150 '

From 1963 to 1969 as part of Project Shipboard Haz¬ ard and Defense (SHAD), the U.S. Army performed tests which involved spraying several U.S. ships with various biological and chemical warfare agents, while thousands of U.S. military personnel were aboard the ships. The personnel were not notified of the tests, and were not given any protective clothing. Chemicals tested on the U.S. military personnel included the nerve gases VX and Sarin, toxic chemicals such as zinc cadmium sulfide and sulfur dioxide, and a variety of biological agents. 1511

In 1966, the U.S. Army released the harmless Bacillus globigii into the tunnels of the New York City Subway sys¬ tem, as part of a field study called A Study of the Vulnera¬ bility of Subway Passengers in New York City to Covert At¬ tack with Biological Agents . ' 46 ' ' 52 ' ' 53 ' ' 54 ' ' 551 The Chicago subway system was also subject to a similar experiment by the Army. [461

3 Human radiation experiments

Main article: Human radiation experiments

Researchers in the United States have performed thou¬ sands of human radiation experiments to determine the effects of atomic radiation and radioactive contamina¬ tion on the human body, generally on people who were poor, sick, or powerless.' 56 ' Most of these tests were per¬ formed, funded, or supervised by the United States mil¬ itary, Atomic Energy Commission, or various other US federal government agencies.

The experiments included a wide array of studies, in¬ volving things like feeding radioactive food to mentally disabled children or conscientious objectors, inserting radium rods into the noses of schoolchildren, deliberately releasing radioactive chemicals over U.S. and Canadian cities, measuring the health effects of radioactive fallout from nuclear bomb tests, injecting pregnant women and babies with radioactive chemicals, and irradiating the tes¬ ticles of prison inmates, amongst other things.

Much information about these programs was classified and kept secret. In 1986 the United States House Com¬ mittee on Energy and Commerce released a report en¬ titled American Nuclear Guinea Pigs : Three Decades of Radiation Experiments on U.S. Citizens ,' 57 ' In the 1990s Eileen Welsome’s reports on radiation testing for The Albuquerque Tribune prompted the creation of the Advisory Committee on Human Radiation Experiments

by executive order of president Bill Clinton, to monitor government tests. It published results in 1995. Welsome later wrote a book called The Plutonium Files.

3.1 Radioactive iodine experiments

In a 1949 operation called the "Green Run,” the AEC re¬ leased iodine-131 and xenon-133 to the atmosphere near the Hanford site in Washington, which contaminated a 500,000-acre (2,000 km 2 ) area containing three small towns.' 581

In 1953, the U.S. Atomic Energy Commission (AEC) ran several studies at the University of Iowa on the health effects of radioactive iodine in newborns and pregnant women. In one study, researchers gave pregnant women from 100 to 200 microcuries (3.7 to 7.4 MBq) of iodine- 13 1, in order to study the women’s aborted embryos in an attempt to discover at what stage, and to what extent, ra¬ dioactive iodine crosses the placental barrier. In another study, they gave 25 newborn babies (who were under 36 hours old and weighed from 5.5 to 8.5 pounds (2.5 to 3.9 kg)) iodine-131, either by oral administration or through an injection, so that they could measure the amount of iodine in their thyroid glands, as iodine would go to that gland.' 591

In another AEC study, researchers at the University of Nebraska College of Medicine fed iodine-131 to 28 healthy infants through a gastric tube to test the concen¬ tration of iodine in the infants’ thyroid glands.' 59 '

In 1953, the AEC sponsored a study to discover if ra¬ dioactive iodine affected premature babies differently from full-term babies. In the experiment, researchers from Harper Hospital in Detroit orally administered iodine-131 to 65 premature and full-term infants who weighed from 2.1 to 5.5 pounds (0.95 to 2.49 kg).' 591

From 1955 to 1960, Sonoma State Hospital in northern California served as a permanent drop-off location for mentally handicapped children diagnosed with cerebral palsy or lesser disorders. The children subsequently un¬ derwent painful experimentation without adult consent. Many were given irradiated milk, some spinal taps “for which they received no direct benefit.” Reporters of 60 Minutes learned that in these five years, the brain of ev¬ ery cerebral palsy child who died at Sonoma State was re¬ moved and studied without parental consent. According to the CBS story, over 1,400 patients died at the clinic.' 601

In an experiment in the 1960s, over 100 Alaskan citizens were continually exposed to radioactive iodine.' 61 '

In 1962, the Hanford site again released 1-131, stationing test subjects along its path to record its effect on them. The AEC also recruited Hanford volunteers to ingest milk contaminated with 1-131 during this time.' 59 '

3.4 Experiments involving other radioactive materials

5

3.2 Uranium experiments

“It is desired that no document be released which refers to experiments with humans and might have adverse ef¬ fect on public opinion or result in legal suits. Documents covering such work should be classified 'secret’.”

April 17, 1947 Atomic Energy Commission memo from Colonel O.G. Haywood, Jr. to Dr. Fidler at the Oak Ridge National Laboratory in Tennessee 162

Between 1946 and 1947, researchers at the University of Rochester injected uranium-234 and uranium-235 in dosages ranging from 6.4 to 70.7 micrograms per kilo¬ gram of body weight into six people to study how much uranium their kidneys could tolerate before becoming damaged. 1631

Between 1953 and 1957, at the Massachusetts General Hospital, Dr. William Sweet injected eleven terminally ill, comatose and semi-comatose patients with uranium in an experiment to determine, among other things, its via¬ bility as a chemotherapy treatment against brain tumors, which all but one of the patients had (one being a mis¬ diagnosis). Dr. Sweet, who died in 2001, maintained that consent had been obtained from the patients and next of kin [64] [65]

3.3 Plutonium experiments

From April 10, 1945 to July 18, 1947, eighteen people were injected with plutonium as part of the Manhattan Project. 1661 Doses administered ranged from 95 to 5,900 nanocuries. 1661

Albert Stevens, a man misdiagnosed with stomach can¬ cer, received “treatment” for his “cancer” at the U.C. San Francisco Medical Center in 1945. Dr. Joseph Gilbert Hamilton, a Manhattan Project doctor in charge of the human experiments in California 1671 had Stevens injected with Pu-238 and Pu-239 without informed con¬ sent. Stevens never had cancer; a surgery to remove can¬ cerous cells was highly successful in removing the benign tumor, and he lived for another 20 years with the injected plutonium. 1681 Since Stevens received the highly radioac¬ tive Pu-238, his accumulated dose over his remaining life was higher than anyone has ever received: 64 Sv (6400 rem). Neither Albert Stevens nor any of his relatives were told that he never had cancer; they were led to believe that the experimental “treatment” has worked. His cre¬ mated remains were surreptitiously acquired by Argonne National Laboratory Center for Human Radiobiology in 1975 without the consent of surviving relatives. Some of the ashes were transferred to the National Human Ra¬ diobiology Tissue Repository at Washington State Uni¬ versity, 1681 which keeps the remains of people who died having radioisotopes in their body.

Three patients at Billings Hospital at the University of

Chicago were injected with plutonium. 1691 In 1946, six employees of a Chicago metallurgical lab were given wa¬ ter that was contaminated with plutonium-239, so that re¬ searchers could study how plutonium is absorbed into the digestive tract. 1631

An eighteen-year-old woman at an upstate New York hos¬ pital, expecting to be treated for a pituitary gland disor¬ der, was injected with plutonium. 1701

3.4 Experiments involving other radioac¬ tive materials

Immediately after World War II, researchers at Vanderbilt University gave 829 pregnant mothers in Tennessee what they were told were “vitamin drinks” that would improve the health of their babies. The mixtures contained radioactive iron and the researchers were determining how fast the radioisotope crossed into the placenta. At least three children are known to have died from the experiments, from cancers and leukemia. 17111721 Four of the women’s babies died from cancers as a result of the experiments, and the women experienced rashes, bruises, anemia, hair/tooth loss, and cancer. 1561

From 1946 to 1953, at the Walter E. Fernald State School in Massachusetts, in an experiment sponsored by the U.S. Atomic Energy Commission and the Quaker Oats corpo¬ ration, 73 mentally disabled children were fed oatmeal containing radioactive calcium and other radioisotopes, in order to track “how nutrients were digested”. The chil¬ dren were not told that they were being fed radioactive chemicals; they were told by hospital staff and researchers that they were joining a “science club”. 171117 -’ 117411751

The University of California Hospital in San Francisco exposed 29 patients, some with rheumatoid arthritis, to total body irradiation (100-300 rad dose) to obtain data for the military. 1761

In the 1950s, researchers at the Medical College of Vir¬ ginia performed experiments on severe burn victims, most of them poor and black, without their knowledge or consent, with funding from the Army and in collabora¬ tion with the AEC. In the experiments, the subjects were exposed to additional burning, experimental antibiotic treatment, and injections of radioactive isotopes. The amount of radioactive phosphorus-32 injected into some of the patients, 500 microcuries (19 MBq), was 50 times the “acceptable” dose for a healthy individual; for people with severe burns, this likely led to significantly increased death rates. 17711781

Between 1948 and 1954, funded by the federal government, researchers at the Johns Hopkins Hos¬ pital inserted radium rods into the noses of 582 Baltimore, Maryland schoolchildren as an alternative to adenoidectomy. 179,18011811 Similar experiments were per¬ formed on over 7,000 U.S. Army and Navy personnel during World War II. 1791 Nasal radium irradiation became

6

5 HUMAN RADIATION EXPERIMENTS

a standard medical treatment and was used in over two and a half million Americans. 1791

In 1951 at Johns Hopkins, Henrietta Lacks had been treated with a radium rod in her cervix, and 2 radium plaques placed on her skin, for a cervical tumor. 1821

In another study at the Walter E. Fernald State School, in 1956, researchers gave mentally disabled children ra¬ dioactive calcium orally and intravenously. They also injected radioactive chemicals into malnourished babies and then pushed needles through their skulls, into their brains, through their necks, and into their spines to col¬ lect cerebrospinal fluid for analysis. 17511831

In 1961 and 1962, ten Utah State Prison inmates had blood samples taken which were mixed with radioactive chemicals and reinjected back into their bodies. 1841

The Atomic Energy Commission funded the Massachusetts Institute of Technology to adminis¬ ter radium-224 and thorium-234 to 20 people between 1961 and 1965. Many were chosen from the Age Center of New England and had volunteered for “research projects on aging”. Doses were 0.2-2.4 microcuries (7.4-88.8 kBq) for radium and 1.2-120 microcuries (44-4,440 kBq) for thorium. 1571

In a 1967 study that was published in the Journal of Clin¬ ical Investigation , pregnant women were injected with ra¬ dioactive cortisol to see if it would cross the placental bar¬ rier and affect the fetuses. 1851

Study of Response of Human Beings Accidentally Exposed to Significant Fallout Radiation

by

E. P. Cronkite. Commander. MC. USN V P. Bond. M.D.. Ph.D.

L. E Browning, Lt. Col., MC, USA W. H. Chapman. Lt., MSC. USN S. H. Cohn, Ph.D.

K. A. Cnnard, Commander, MC. USN C. L. Dunham, M.D.

R. S. Farr, Lt.. MC. USN

Cover of the final report of Project 4.1, which examined the ef¬ fects of radioactive fallout on the natives of the Marshall Islands

3.5 Fallout research

In 1957, atmospheric nuclear explosions in Nevada, which were part of Operation Plumbbob were later deter¬ mined to have released enough radiation to have caused from 11,000 to 212,000 excess cases of thyroid cancer among U.S. citizens who were exposed to fallout from the explosions, leading to between 1,100 and 21,000 deaths. 1861

Early in the Cold War, in studies known as Project GABRIEL and Project SUNSHINE, researchers in the United States, the United Kingdom, and Australia tried to determine how much nuclear fallout would be required to make the Earth uninhabitable. 18711881 They realized that atmospheric nuclear testing had provided them an op¬ portunity to investigate this. Such tests had dispersed radioactive contamination worldwide, and examination of human bodies could reveal how readily it was taken up and hence how much damage it caused. Of particular interest was strontium— 90 in the bones. Infants were the primary focus, as they would have had a full opportunity to absorb the new contaminants. 1891 1901 As a result of this conclusion, researchers began a program to collect human bodies and bones from all over the world, with a particular focus on infants. The bones were cremated and the ashes analyzed for radioisotopes. This project was kept secret primarily because it would be a public relations disaster;

as a result parents and family were not told what was be¬ ing done with the body parts of their relatives. 1911

3.6 Irradiation experiments

Between 1960 and 1971, the Department of Defense funded non-consensual whole body radiation experiments on poor, black cancer patients, who were not told what was being done to them. Patients were told that they were receiving a “treatment” that might cure their cancer, but the Pentagon was trying to determine the effects of high levels of radiation on the human body. One of the doctors involved in the experiments, Robert Stone, was worried about litigation by the patients. He referred to them only by their initials on the medical reports. He did this so that, in his words, “there will be no means by which the patients can ever connect themselves up with the report”, in order to prevent “either adverse publicity or litigation”. 1921

From 1960 to 1971, Dr. Eugene Saenger, funded by the Defense Atomic Support Agency, performed whole body radiation experiments on more than 90 poor, black, ter¬ minally ill cancer patients with inoperable tumors at the University of Cincinnati Medical Center. He forged con¬ sent forms, and did not inform the patients of the risks of irradiation. The patients were given 100 or more rads (1 Gy) of whole-body radiation, which in many caused intense pain and vomiting. Critics have questioned the

7

medical rationale for this study, and contend that the main purpose of the research was to study the acute effects of radiation exposure. 19311941

From 1963 to 1973, a leading endocrinologist. Dr. Carl Heller, irradiated the testicles of Oregon and Washington prisoners. In return for their participation, he gave them $5 a month, and $100 when they had to receive a vasectomy upon conclusion of the trial. The surgeon who sterilized the men said that it was necessary to “keep from contaminating the general population with radiation-induced mutants". Dr. Joseph Hamilton, one of the researchers who had worked with Heller on the ex¬ periments, said that the experiments “had a little of the Buchenwald touch”. 1951

In 1963, University of Washington researchers irradiated the testes of 232 prisoners to determine the effects of ra¬ diation on testicular function. When these inmates later left prison and had children, at least four of them had offspring born with birth defects. The exact number is unknown because researchers never followed up on the status of the subjects. 1961

4 Chemical experiments

From 1942 to 1944, the U.S. Chemical Warfare Ser¬ vice conducted experiments which exposed thousands of U.S. military personnel to mustard gas, in order to test the effectiveness of gas masks and protective clothing. 1971 [98][99][1001

From 1950 through 1953, the U.S. Army sprayed chemi¬ cals over six cities in the United States and Canada, in or¬ der to test dispersal patterns of chemical weapons. Army records stated that the chemicals which were sprayed on the city of Winnipeg, Canada, included zinc cadmium sulfide, which was not thought to be harmful. 11011 A 1997 study by the US National Research Council found that it was sprayed at levels so low as not be harmful; it said that people were normally exposed to higher levels in urban environments.

To test whether or not sulfuric acid, which is used in making molasses, was harmful as a food additive, the Louisiana State Board of Health commissioned a study to feed “Negro prisoners” nothing but molasses for five weeks. One report stated that prisoners didn't “object to submitting themselves to the test, because it would not do any good if they did”. 1141

A 1953 article in the medical/scientific journal Clinical Science 11021 described a medical experiment in which re¬ searchers intentionally blistered the skin on the abdomens of 41 children, who ranged in age from 8 to 14, using cantharide. The study was performed to determine how severely the substance injures/irritates the skin of chil¬ dren. After the studies, the children’s blistered skin was removed with scissors and swabbed with peroxide. 1851

Chloracne resulting from exposure to dioxins, such as those that Albert Kligman injected into prisoners at the Holmesburg Prison

From approximately 1951 to 1974, the Holmesburg Prison in Pennsylvania was the site of extensive dermatological research operations, using prisoners as subjects. Led by Dr. Albert M. Kligman of the University of Pennsylvania, the studies were performed on behalf of Dow Chemical Company, the U.S. Army, and Johnson & Johnson. 110311104111051 In one of the studies, for which Dow Chemical paid Kligman $10,000, Klig¬ man injected dioxin — a highly toxic, carcinogenic com¬ pound found in Agent Orange, which Dow was manufac¬ turing for use in Vietnam at the time — into 70 prisoners (most of them black). The prisoners developed severe lesions which went untreated for seven months. 1121 Dow Chemical wanted to study the health effects of dioxin and other herbicides, and how they affect human skin, because workers at their chemical plants were develop¬ ing chloracne. In the study, Kligman applied roughly the same amount of dioxin as that to which Dow employees were being exposed. In 1980 and 1981, some of the peo¬ ple who were used in this study sued Professor Kligman for a variety of health problems, including lupus and psy¬ chological damage. 11061

Kligman later continued his dioxin studies, increasing the dosage of dioxin he applied to the skin of 10 prisoners to 7,500 micrograms of dioxin, which is 468 times the dosage that the Dow Chemical official Gerald K. Rowe had authorized him to administer. As a result, the pris¬ oners developed inflammatory pustules and papules. 11061

The Holmesburg program paid hundreds of inmates a nominal stipend to test a wide range of cosmetic prod-

8

ucts and chemical compounds, whose health effects were unknown at the time. 1 107111081 Upon his arrival at Holmes- berg, Kligman is claimed to have said, “All I saw before me were acres of skin ... It was like a farmer seeing a fer¬ tile field for the first time”. 1 1091 A 1964 issue of Medical News reported that 9 out of 10 prisoners at Holmesburg Prison were medical test subjects. 11101

In 1967, the U.S. Army paid Kligman to apply skin- blistering chemicals to the faces and backs of inmates at Holmesburg to, in Kligman’s words, “learn how the skin protects itself against chronic assault from toxic chemi¬ cals, the so-called hardening process.” 11061

5 Psychological and torture experi¬ ments

5.1 U.S. government research

The United States government funded and performed numerous psychological experiments, especially during the Cold War era. Many of these experiments were performed to help develop more effective torture and interrogation techniques for the U.S. military and intel¬ ligence agencies, and to develop techniques for Ameri¬ cans to resist torture at the hands of enemy nations and organizations.

5.1.1 Truth serum

In studies running from 1947 to 1953, which were known as Project Chatter, the U.S. Navy began identifying and testing truth serums, which they hoped could be used dur¬ ing interrogations of Soviet spies. Some of the chemi¬ cals tested on human subjects included mescaline and the anticholinergic drug scopolamine. 1 1111

Shortly thereafter, in 1950, the CIA initiated Project Bluebird, later renamed Project Artichoke, whose stated purpose was to develop “the means to control individu¬ als through special interrogation techniques”, “way[s] to prevent the extraction of information from CIA agents”, and “offensive uses of unconventional techniques, such as hypnosis and drugs”. 111111112111131 The purpose of the project was outlined in a memo dated lanuary 1952 that stated, “Can we get control of an individual to the point where he will do our bidding against his will and even against fundamental laws of nature, such as self preser¬ vation?" The project studied the use of hypnosis, forced morphine addiction and subsequent forced withdrawal, and the use of other chemicals, among other meth¬ ods, to produce amnesia and other vulnerable states in subjects. 1114111151111611117111181 In order to “perfect tech¬ niques for the abstraction of information from individu¬ als, whether willing or not”. Project Bluebird researchers experimented with a wide variety of psychoactive sub¬ stances, including LSD, heroin, marijuana, cocaine, PCP,

5 PSYCHOLOGICAL AND TORTURE EXPERIMENTS

mescaline, and ether. 11191 Project Bluebird researchers dosed over 7,000 U.S. military personnel with LSD, with¬ out their knowledge or consent, at the Edgewood Arse¬ nal in Maryland. Years after these experiments, more than 1,000 of these soldiers suffered from several psychi¬ atric illnesses, including depression and epilepsy. Many of them tried to commit suicide. 11201

5.1.2 Drug deaths

In 1952, professional tennis player Harold Blauer died when injected by Dr. James Cattell with a fatal dose of a mescaline derivative at the New York State Psychi¬ atric Institute of Columbia University. The United States Department of Defense, which sponsored the injection, worked in collusion with the Department of Justice and the New York State Attorney General to conceal evidence of its involvement for 23 years. Cattell claimed that he did not know what the army had given him to inject into Blauer, saying: “We didn't know whether it was dog piss or what we were giving him.” 1121111221

On November 19, 1953 Dr. Frank Olson was without his knowledge or consent given an LSD dosage before his death 9 days later. For 22 years this was covered up until the Project MKUltra revelations.

5.1.3 MKULTRA

Founding In 1953, the CIA placed several of its in¬ terrogation and mind-control programs under the di¬ rection of a single program, known by the code name MKULTRA, after CIA director Allen Dulles complained about not having enough “human guinea pigs to try these extraordinary techniques”. 11231 The MKULTRA project was under the direct command of Dr. Sidney Gottlieb of the Technical Services Division. 11231 The project received over $25 million, and involved hundreds of experiments on human subjects at eighty different institutions.

In a memo describing the purpose of one MKULTRA program subprogram, Richard Helms said:

We intend to investigate the development of a chemical material which causes a re¬ versible, nontoxic aberrant mental state, the specific nature of which can be reasonably well predicted for each individual. This material could potentially aid in discrediting individ¬ uals, eliciting information, and implanting suggestions and other forms of mental control.

—Richard Helms, internal CIA memo 11241

In 1954, the CIA’s Project QKHILLTOP was created to study Chinese brainwashing techniques, and to de¬ velop effective methods of interrogation. Most of the early studies are believed to have been performed by

5.1 U.S. government research

9

the Cornell University Medical School’s human ecol¬ ogy study programs, under the direction of Dr. Harold Wolff. I 111 ! [125] [ 126 J Wolff' requested that the CIA provide him any information they could find regarding “threats, coercion, imprisonment, deprivation, humiliation, tor¬ ture, 'brainwashing', 'black psychiatry', and hypnosis, or any combination of these, with or without chemical agents”. According to Wolff, the research team would then:

...assemble, collate, analyze and assimilate this information and will then undertake ex¬ perimental investigations designed to develop new techniques of offensive/defensive intel¬ ligence use ... Potentially useful secret drugs (and various brain damaging procedures) will be similarly tested in order to ascertain the fundamental effect upon human brain function and upon the subject’s mood ... Where any of the studies involve potential harm of the sub¬ ject, we expect the Agency to make available suitable subjects and a proper place for the performance of the necessary experiments.

—Dr. Harold Wolff, Cornell University

Medical School 11261

"... it was fun, fun, fun. Where else could a red-blooded American boy lie, kill, cheat, steal, rape and pillage with the sanction and bidding of the All-highest?"

George Hunter White, who oversaw drug experiments for the CIA as part of Operation Midnight Climax 11271

Another of the MKULTRA subprojects. Operation Mid¬ night Climax, consisted of a web of CIA-run safehouses in San Francisco, Marin, and New York which were es¬ tablished in order to study the effects of LSD on uncon¬ senting individuals. Prostitutes on the CIA payroll were instructed to lure clients back to the safehouses, where they were surreptitiously plied with a wide range of sub¬ stances, including LSD, and monitored behind one-way glass. Several significant operational techniques were de¬ veloped in this theater, including extensive research into sexual blackmail, surveillance technology, and the possi¬ ble use of mind-altering drugs in field operations. 11271

In 1957, with funding from a CIA front organization. Dr. Ewan Cameron of the Allan Memorial Institute in Montreal, Canada began MKULTRA Subproject 68. 11281 His experiments were designed to first “depattern” in¬ dividuals, erasing their minds and memories—reducing them to the mental level of an infant—and then to “re¬ build” their personality in a manner of his choosing. 11291 To achieve this, Cameron placed patients under his “care” into drug-induced comas for up to 88 days, and applied numerous high voltage electric shocks to them over the course of weeks or months, often administering up to 360 shocks per person. He would then perform what he called

“psychic driving” experiments on the subjects, where he would repetitively play recorded statements, such as “You are a good wife and mother and people enjoy your com¬ pany”, through speakers he had implanted into blacked- out football helmets that he bound to the heads of the test subjects (for sensory deprivation purposes). The patients could do nothing but listen to these messages, played for 16-20 hours a day, for weeks at a time. In one case, Cameron forced a person to listen to a message non-stop for 101 days. 11291 Using CIA funding, Cameron converted the horse stables behind Allen Memorial into an elaborate isolation and sensory deprivation chamber which he kept patients locked in for weeks at a time. 11291 Cameron also induced insulin comas in his subjects by giving them large injections of insulin, twice a day, for up to two months at a time. 11111 Several of the children who Cameron exper¬ imented on were sexually abused, in at least one case by several men. One of the children was filmed numerous times performing sexual acts with high-ranking federal government officials, in a scheme set up by Cameron and other MKULTRA researchers, to blackmail the officials to ensure further funding for the experiments. 11301

“The frequent screams of the patients that echoed through the hospital did not deter Cameron or most of his asso¬ ciates in their attempts to depattern their subjects com¬ pletely.”

John D. Marks, The Search for the Manchurian Candi¬ date. Chapter 8 11311

Concerns The CIA leadership had serious concerns about these activities, as evidenced in a 1957 Inspector General Report, which stated:

Precautions must be taken not only to protect operations from exposure to enemy forces but also to conceal these activities from the American public in general. The knowledge that the agency is engaging in unethical and illicit activities would have seri¬ ous repercussions in political and diplomatic circles ...

—1957 CIA Inspector General Report 11321

In 1963, CIA had synthesized many of the find¬ ings from its psychological research into what became known as the KUBARK Counterintelligence Interroga¬ tion handbook, 11331 which cited the MKULTRA studies and other secret research programs as the scientific ba¬ sis for their interrogation methods. 11291 Cameron regu¬ larly traveled around the U.S. teaching military personnel about his techniques (hooding of prisoners for sensory deprivation, prolonged isolation, humiliation, etc.), and how they could be used in interrogations. Latin American paramilitary groups working for the CIA and U.S. mili¬ tary received training in these psychological techniques

10

5 PSYCHOLOGICAL AND TORTURE EXPERIMENTS

at places such as the School of the Americas. In the 21st century, many of the torture techniques developed in the MKULTRA studies and other programs are being used at U.S. military and CIA prisons such as Guantanamo Bay and Abu Ghraib. 1129111341 In the aftermath of the Congres¬ sional hearings, major news media mainly focused on sen- sationalistic stories related to LSD, “mind-control”, and “brainwashing”, and rarely used the word “torture”. This suggested that CIA researchers were, as one author put it “a bunch of bumbling sci-fi buffoons”, rather than a rational group of men who had run torture laboratories and medical experiments in major U.S. universities; they had arranged for torture, rape and psychological abuse of adults and young children, driving many of them perma¬ nently insane. 11291

Shutdown MKULTRA activities continued until 1973 when CIA director Richard Helms, fearing that they would be exposed to the public, ordered the project terminated, and all of the files destroyed. 11231 But, a clerical error had sent many of the documents to the wrong office, so when CIA workers were destroying the files, some of them remained. They were later re¬ leased under a Freedom of Information Act request by investigative journalist John Marks. Many people in the American public were outraged when they learned of the experiments, and several congressional investiga¬ tions took place, including the Church Committee and the Rockefeller Commission.

On April 26, 1976, the Church Committee of the United States Senate issued a report. Final Report of the Select Committee to Study Governmental Operation with Respect to Intelligence Activities , 11351 In Book I, Chapter XVII, p. 389, this report states:

LSD was one the materials tested in the MKULTRA program. The final phase of LSD testing involved surreptitious administration to unwitting non-volunteer subjects in normal fife settings by undercover officers of the Bureau of Narcotics acting for the CIA.

A special procedure, designated MKDELTA, was established to govern the use of MKULTRA materials abroad. Such materials were used on a number of occasions. Because MKULTRA records were destroyed, it is impossible to reconstruct the operational use of MKULTRA materials by the CIA overseas; it has been determined that the use of these materials abroad began in 1953, and possibly as early as 1950. [114][136][137][138][139]

Drugs were used primarily as an aid to interrogations, but MKUL- TRA/MKDELTA materials were also used for harassment, discrediting, or disabling purposes. [114][136][137][138][139]

5.1.4 Schizophrenic patient experiments

Dr. Robert Heath of Tulane University performed ex¬ periments on schizophrenic patients and prisoners in the Louisiana State Penitentiary. The experiments were funded by the U.S. Army. In the studies, he dosed them with LSD and Bulbocapnine, and implanted electrodes into the septal area of the brain to stimulate 1 1401 it and take EEG readings. 1141111421

5.1.5 Torture experiments

From 1964 to 1968, the U.S. Army paid $386,486 to professors Albert Kligman and Herbert W. Copelan to perform experiments with mind-altering drugs on 320 in¬ mates of Holmesburg Prison. The goal of the study was to determine the minimum effective dose of each drug needed to disable 50 percent of any given population. Kligman and Copelan initially claimed that they were un¬ aware of any long-term health effects the drugs could have on prisoners; however, documents later revealed that this was not the case. 11061

Medical professionals gathered and collected data on the CIA’s use of torture techniques on detainees during the 21st century war on terror, in order to refine those tech¬ niques, and “to provide legal cover for torture, as well as to help justify and shape future procedures and poli¬ cies”, according to a 2010 report by Physicians for Hu¬ man Rights. The report stated that: “Research and med¬ ical experimentation on detainees was used to measure the effects of large-volume waterboarding and adjust the procedure according to the results.” As a result of the wa¬ terboarding experiments, doctors recommended adding saline to the water “to prevent putting detainees in a coma or killing them through over-ingestion of large amounts of plain water.” Sleep deprivation tests were performed on over a dozen prisoners, in 48-, 96- and 180-hour in¬ crements. Doctors also collected data intended to help them judge the emotional and physical effects of the techniques so as to “calibrate the level of pain expe¬ rienced by detainees during interrogation” and to de¬ termine if using certain types of techniques would in¬ crease a subject’s “susceptibility to severe pain.” In 2010 the CIA denied the allegations, claiming they never per¬ formed any experiments, and saying “The report is just wrong"; however, the U.S. government never investi¬ gated the claims. 114311144111451114611147111481 The psycholo¬ gists James Mitchell and Bruce Jessen ran a company that was paid $81 million by the CIA, that, according to the Senate Intelligence Committee report on CIA tor¬ ture, developed the “enhanced interrogation techniques” used. 11491 In November 2014, the American Psychologi¬ cal Association announced that they would hire a lawyer to investigate claims that they were complicit in the devel¬ opment of enhanced interrogation techniques that consti¬ tuted torture. 11501

In August 2010, the U.S. weapons manufacturer

11

Raytheon announced that it had partnered with a jail in Castaic, California in order to use prisoners as test subjects for its Active Denial System system that “fires an invisible heat beam capable of causing unbearable pain.” 11511 The device, dubbed “pain ray” by its critics, was rejected for fielding in Iraq due to Pentagon fears that it would be used as an instrument of torture. 1 1521

5.2 Academic research

In 1939, at the Iowa Soldiers’ Orphans’ Home in Davenport, Iowa, twenty-two children were the subjects of the so-called “monster” experiment. This experiment attempted to use psychological abuse to induce stuttering in children who spoke normally. The experiment was de¬ signed by Dr. Wendell Johnson, one of the nation’s most prominent speech pathologists, for the purpose of testing one of his theories on the cause of stuttering. 11531

In 1961, in response to the Nuremberg Trials, the Yale psychologist Stanley Milgram performed his “Obedience to Authority Study”, also known as the Milgram Experi¬ ment, in order to determine if it was possible that the Nazi genocide could have resulted from millions of people who were “just following orders”. The Milgram Experiment raised questions about the ethics of scientific experimen¬ tation because of the extreme emotional stress suffered by the participants, who were told, as part of the experi¬ ment, to apply electric shocks to test subjects (who were actors and did not really receive electric shocks).

In 1971, Stanford University psychologist Philip Zim- bardo conducted the Stanford prison experiment in which twenty-four male students were randomly assigned roles of prisoners and guards in a mock prison situated in the basement of the Stanford psychology building. The par¬ ticipants adapted to their roles beyond Zimbardo’s expec¬ tations with prison guards exhibiting authoritarian status and psychologically abusing the prisoners who were pas¬ sive in their acceptance of the abuse. The experiment was largely controversial with criticisms aimed toward the lack of scientific principles and a control group, and for ethical concerns regarding Zimbardo’s lack of interven¬ tion in the prisoner abuse.

6 Pharmacological research

At Harvard University, in the late 1940s, researchers began performing experiments in which they tested diethylstilbestrol, a synthetic estrogen, on pregnant women at the Lying-In Hospital of the University of Chicago. The women experienced an abnormally high number of miscarriages and babies with low birth weight (LBW). None of the women were told that they were be¬ ing experimented on. 11541

In 1962, researchers at the Laurel Children’s Center in Maryland tested experimental acne medications on

children. They continued their tests even after half of the children developed severe liver damage from the medications. 1851

In 2004, University of Minnesota research participant Dan Markingson committed suicide while enrolled in an industry-sponsored pharmaceutical trial comparing three FDA-approved atypical antipsychotics: Seroquel (que- tiapine), Zyprexa (olanzapine), and Risperdal (risperi¬ done). Writing on the circumstances surrounding Mark- ingson’s death in the study, which was designed and funded by Seroquel manufacturer AstraZeneca, Uni¬ versity of Minnesota Professor of Bioethics Carl El¬ liott noted that Markingson was enrolled in the study against the wishes of his mother, Mary Weiss, and that he was forced to choose between enrolling in the study or being involuntarily committed to a state men¬ tal institution. 11551 Further investigation revealed finan¬ cial ties to AstraZeneca by Markingson’s psychiatrist. Dr. Stephen C. Olson, oversights and biases in As¬ traZeneca’s trial design, and the inadequacy of univer¬ sity Institutional Review Board (IRB) protections for re¬ search subjects. 11561 A 2005 FDA investigation cleared the university. Nonetheless, controversy around the case has continued. Mother Jones resulted in a group of uni¬ versity faculty members sending a public letter to the uni¬ versity Board of Regents urging an external investigation into Markingson’s death. 11571

7 Other experiments

The 1846 journals of Dr. Walter F. Jones of Peters¬ burg, Virginia, describe how he poured boiling water onto the backs of naked slaves afflicted with typhoid pneumonia, at four-hour intervals, because he thought that this might “cure” the disease by “stimulating the capillaries”. 1 15811159111601

From early 1940 until 1953, Dr. Lauretta Bender, a highly respected pediatric neuropsychiatrist who prac¬ ticed at Bellevue Hospital in New York City, performed electroshock experiments on at least 100 children. The children’s ages ranged from 3-12 years. Some reports indicate that she may have performed such experiments on more than 200. From 1942 to 1956, electroconvul¬ sive treatment was used on more than 500 children at Bellevue Hospital, including Bender’s experiments; from 1956 to 1969, ECT was used at Creedmoor State Hos¬ pital Children’s Service. Publicly, Bender claimed that the results of the “therapy” were positive, but in private memos, she expressed frustration over mental health is¬ sues caused by the treatments. 11611 Bender would some¬ times shock schizophrenic children (some less than 3 years old) twice per day, for 20 consecutive days. Several of the children became violent and suicidal as a result of the treatments. 11621

In 1942, the Harvard University biochemist Edward

12

8 LEGAL, ACADEMIC AND PROFESSIONAL POLICY

Cohn injected 64 Massachusetts prisoners with cow blood, as part of an experiment sponsored by the U.S. Navy. 116311164111651

In 1950, researchers at the Cleveland City Hospital ran experiments to study changes in cerebral blood flow: they injected people with spinal anesthesia, and inserted nee¬ dles into their jugular veins and brachial arteries to extract large quantities of blood and, after massive blood loss which caused paralysis and fainting, measured their blood pressure. The experiment was often performed multiple times on the same subject. 1851

In a series of studies which were published in the medi¬ cal journal Pediatrics, researchers from the University of California Department of Pediatrics performed experi¬ ments on 113 newborns ranging in age from 1-hour to 3 days, in which they studied changes in blood pressure and blood flow. In one of the studies, researchers inserted a catheter through the babies’ umbilical arteries and into their aortas, and then submerged their feet in ice water. In another of the studies, they strapped 50 newborn babies to a circumcision board, and turned them upside down so that all of their blood rushed into their heads. 1851

The San Antonio Contraceptive Study was a clinical research study published in 1971 about the side ef¬ fects of oral contraceptives. Women coming to a clinic in San Antonio to prevent pregnancies were not told they were participating in a research study or receiving placebos. 10 of the women became pregnant while on placebos. 1166111671 11681

In the 2000s (decade), artificial blood was transfused into research subjects across the United States without their consent by Northfield Labs. 11691 Later studies showed the artificial blood caused a significant increase in the risk of heart attacks and death. 1 1701

8 Legal, academic and professional policy

Main article: Human subject research legislation in the United States

During the Nuremberg Medical Trials, several of the Nazi doctors and scientists who were being tried for their human experiments cited past unethical studies per¬ formed in the United States in their defense, namely the Chicago malaria experiments conducted by Dr. Joseph Goldberger. 112,1501 Subsequent investigation led to a re¬ port by Andrew Conway Ivy, who testified that the re¬ search was “an example of human experiments which were ideal because of their conformity with the high¬ est ethical standards of human experimentation”. 1 171 ' The trials contributed to the formation of the Nuremberg Code in an effort to prevent such abuses. 11721

A secret AEC document dated April 17, 1947, titled

Medical Experiments in Humans stated: “It is desired that no document be released which refers to experi¬ ments with humans that might have an adverse reaction on public opinion or result in legal suits. Documents cov¬ ering such fieldwork should be classified Secret.” 1591

At the same time, the Public Health Service was in¬ structed to tell citizens downwind from bomb tests that the increases in cancers were due to neurosis, and that women with radiation sickness, hair loss, and burned skin were suffering from “housewife syndrome”. 1591

In 1964, the World Medical Association passed the Declaration of Helsinki, a set of ethical principles for the medical community regarding human experimentation.

In 1966, the United States National Institutes of Health (NIH) Office for Protection of Research Subjects (OPRR) was created. It issued its Policies for the Protec¬ tion of Human Subjects, which recommended establish¬ ing independent review bodies to oversee experiments. These were later called institutional review boards.

In 1969, Kentucky Court of Appeals Judge Samuel Ste- infeld dissented in Strunk v>. Strunk, 445 S.W.2d 145. He made the first judicial suggestion that the Nuremberg Code should be applied to American jurisprudence.

In 1974 the National Research Act established the Na¬ tional Commission for the Protection of Human Subjects. It mandated that the Public Health Service come up with regulations to protect the rights of human research sub¬ jects.

Project MK-ULTRA was first brought to wide public at¬ tention in 1975 by the U.S. Congress, through inves¬ tigations by the Church Committee, and by a presi¬ dential commission known as the Rockefeller Commis¬ sion. 1173111741

In 1975, the Department of Health, Education and Wel¬ fare (DHEW) created regulations which included the rec¬ ommendations laid out in the NIH’s 1966 Policies for the Protection of Human Subjects. Title 45 of the Code of Federal Regulations, known as “The Common Rule,” requires the appointment and use of institutional review boards (IRBs) in experiments using human subjects.

On April 18, 1979, prompted by an investigative jour¬ nalist’s public disclosure of the Tuskegee syphilis exper¬ iments, the United States Department of Health, Educa¬ tion, and Welfare (later renamed to Health and Human Services) released a report entitled Ethical Principles and Guidelines for the Protection of Human Subjects of Re¬ search, written by Dan Harms. It laid out many modern guidelines for ethical medical research.

In 1987 the United States Supreme Court ruled in United States v. Stanley, 483 U.S. 669, that a U.S. serviceman who was given LSD without his consent, as part of mili¬ tary experiments, could not sue the U.S. Army for dam¬ ages.

Dissenting the verdict in U.S. v. Stanley, Justice Sandra

13

Day O'Connor stated:

No judicially crafted rule should insulate from liability the involuntary and unknowing human experimentation alleged to have oc¬ curred in this case. Indeed, as Justice Bren¬ nan observes, the United States played an in¬ strumental role in the criminal prosecution of Nazi scientists who experimented with human subjects during the Second World War, and the standards that the Nuremberg Military Tri¬ bunals developed to judge the behavior of the defendants stated that the 'voluntary consent of the human subject is absolutely essential ... to satisfy moral, ethical, and legal concepts.' If this principle is violated, the very least that so¬ ciety can do is to see that the victims are com¬ pensated, as best they can be, by the perpetra¬ tors.

On January 15, 1994, President Bill Clinton formed the Advisory Committee on Human Radiation Experiments (ACHRE). This committee was created to investigate and report the use of human beings as test subjects in experi¬ ments involving the effects of ionizing radiation in feder¬ ally funded research. The committee attempted to deter¬ mine the causes of the experiments and reasons that the proper oversight did not exist. It made several recom¬ mendations to help prevent future occurrences of similar events. 11731

As of 2007, not a single U.S. government researcher had been prosecuted for human experimentation. The pre¬ ponderance of the victims of U.S. government experi¬ ments have not received compensation or, in many cases, acknowledgment of what was done to them. 11761

9 See also

• Belmont Report

• Eugenics in the United States

• Henry Cotton (doctor)

• Human rights in the United States

• Japanese human experimentation

• Nazi human experimentation

• North Korean human experimentation

• Operation Big Buzz

• Operation Crossroads

• Operation Dew

• Operation Drop Kick

• Operation LAC

• Operation May Day

• Project MKUltra

• Poison laboratory of the Soviet secret services

• Research involving prisoners

10 References

10.1 Notes

[1] Hornblum Allen M.; Newman Judith Lynn; Dober Gre¬ gory J. (2013). Against Their Will: The Secret History of Medical Experimentation on Children in Cold War Amer¬ ica. Palgrave Macmillan. ISBN 978-0-230-34171-5.

[2] Some defend 'father of gynecology' by Barron H. Lerner, The Tuscaloosa News, Oct 30. 2003 (accessed: 02/17/2010)

[3] Washington, 2008: pp. 62-63

[4] Cina & Perper, 2010: p. 88

[5] Washington, 2008: pp. 66

[6] Lederer. 1997: pp. 7-8

[7] Grodin & Glantz, 1994: pp. 7-11

[8] The Strange Career of Leo Stanley: Remaking Man¬ hood and Medicine at San Quentin State Peniten¬ tiary, 1913-1951, Ethan Blue, Pacific Historical Review, May 2009, Vol. 78, No. 2, pp. 210-241, DOI 10.1525/phr.2009.78.2.210

[9] Hornblum, 1998: p. 79

[10] Lederer. 1997: p. 3

[11] Shamoo & Resnick, 2009: pp. 238-239

[12] Germ War: The US Record - Alexander Cockburn, Counterpunch

[13] Cina & Perper, 2010: p. 89

[14] Hornblum, 1998: pp. 76-77

[15] Roger Cooter (1992). In the Name of the Child. Rout- ledge. pp. 104-105. ISBN 978-0-203-41223-7.

[16] Reviews and Notes: History of Medicine: Subjected to Science: Human Experimentation in America before the Second World War, Annals of Internal Medicine, American College of Physicians, July 15, 1995 vol. 123 no. 2 159

[17] “Tuskegee Study - Timeline". NCHHSTP. CDC. June 25, 2008. Retrieved 2008-12-04.

[ 18] The Tuskegee Syphilis Experiment Borgna Brunner. Re¬ trieved 2010-03-25

14

10 REFERENCES

[19] Meiklejohn, Gordon N., M.D. “Commission on In¬ fluenza.” in Histories’ of the Commissions Ed. Theodore E. Woodward. M.D., The Armed Forced Epidemiologi¬ cal Board, 1994

[20] Halpern. 2006: p. 199

[21] Lederer, Susan E. Subjected to Science: Human Experi¬ mentation in America before the Second World War, Johns Hopkins University Press, 1995/1997

[22] Grodin & Glantz, 1994: p. 14

[23] Brody, 1998: p. 120

[24] Cina & Perper, 2010: p. 94

[25] Black WC (February 1942). “The etiology of acute infec¬ tious gingivostomatitis (Vincent’s stomatitis)". The Jour¬ nal of Pediatrics 20 (2): 145-60. doi:10.1016/S0022- 3476(42)80125-0.

[26] George Annas & Michael Grodin, 1995: p. 267

[27] Homblum, 1999: p. 76

[28] Rothman, 1992: p.36

[29] “U.S. sorry for Guatemala syphilis experiment”. CBC News. October 1, 2010.

[30] Rob Stein (October 1, 2010). “U.S. apologizes for newly revealed syphilis experiments done in Guatemala”. The Washington Post.

[31] “US sorry over deliberate sex infections in Guatemala”.

BBC News. October 1, 2010.

[32] Chris McGreal (October 1, 2010). “US says sorry for 'out¬ rageous and abhorrent' Guatemalan syphilis tests”. The Guardian (London).

[33] Moreno, 2001: pp. 233-234

[34] Blum, William (2006). Rogue State: A Guide to the World’s Only Superpower. Zed Books, pp. 147-149.

ISBN 978-1-84277-827-2.

[35] “How the U.S. Government Exposed Thousands of Amer¬ icans to Lethal Bacteria to Test Biological Warfare”, Democracy Now!, July 13, 2005

[36] Howard Gordon Wilshire, Jane E. Nielson, Richard W. Hazlett (2008). The American West at Risk: Science,

Myths, and Politics of Land Abuse and Recovery. Oxford University Press, p. 176. ISBN 978-0-19-514205-1.

[37] Tansey. Bernadette (October 31, 2004). “Serratia has dark history in region: Army test in 1950 may have changed microbial ecology”. San Francisco Chronicle.

[38] Ania BJ (October 1, 2008). “Serratia: Overview”. eMedicine. WebMD. Retrieved November 23, 2011.

[39] Cole, 1996: p. 17

[40] Melnick, Alan L. (2008). Biological, Chemical, and Ra-

diological Terrorism: Emergency Preparedness and Re¬ sponse for the Primary Care Physician. Springer, p. 2. [60]

ISBN 978-0-387-47231-7.

[41] Homblum, 1998: p. 91

[42] Frederick Adolf Paola, Robert Walker, Lois Lacivita Nixon, ed. (2009). Medical Ethics and Humanities. Jones & Bartlett Publishers, pp. 185-186. ISBN 978-0-7637- 6063-2.

[43] Hammer Breslow, Lauren. “The Best Pharmaceuticals for Children Act of 2002: The Rise of the Voluntary Incentive Structure and Congressional Refusal to Require Pediatric Testing”, Harvard Journal of Legislation, Vol. 40

[44] Offit, Paul A. (2007). The Cutter Incident: How America’s First Polio Vaccine Led to the Growing Vaccine Crisis. Yale University Press, p. 37. ISBN 978-0-300-12605-1.

[45] Goliszek, 2003: p. 228

[46] Blum, William (2006). Rogue state: a guide to the world's only superpower. Zed Books, pp. 150-151. ISBN 978- 1-84277-827-2.

[47] Michael Parenti, The Sword and the Dollar: Imperialism,

Revolution, and the Arms Race, St. Martins Press, 1989, pp.74-81. Excerpt available online at: (Retrieved Febru¬ ary 18, 2010)

[48] Biological Warfare and the National Security State: A Chronology, Tom Burghardt

[49] https://www.metabunk.org/threads/ debunked-cias-whooping-cough-experiment-in-1955-kills- 12-people. 630/

[50] Loue. 2000: pp. 26-29

[51] Blum, William (2006). Rogue State: A Guide to the World’s Only Superpower. Zed Books, pp. 152-154.

ISBN 978-1-84277-827-2.

[52] Moreno, 2001: p. 234

[53] Cina & Perper, 2010: p. 95

[54] Wheelis, Mark;Rozsa, Lajos; Dando, Malcolm (2006).

Deadly cultures: biological weapons since 1945. Harvard University Press, pp. 27-28. ISBN 978-0-674-01699-6.

[55] “How the U.S. Government Exposed Thousands of Amer¬ icans to Lethal Bacteria to Test Biological Warfare”. Democracynow.org. 2005-07-13. Retrieved 2012-12-16.

[56] Loue, 2000: pp. 19-23

[57] American Nuclear Guinea Pigs : Three Decades of Ra¬ diation Experiments on U.S. Citizens. United States.

Congress. House, of the Committee on Energy and Commerce. Subcommittee on Energy Conservation and Power, published by U.S. Government Printing Office,

1986, Identifier Y 4.En 2/3:99-NN, Electronic Publi¬ cation Date 2010, at the University of Nevada, Reno, unr.edu

Goliszek, 2003: pp. 130-131 Goliszek, 2003: pp. 132-134

Rebecca Leung. "A Dark Chapter In Medical History".

CBS News, 11 February 2009.

10.1 Notes

15

[61] Perni, Holliston (2005). A Heritage of Hypocrisy. Pleas¬ ant Mount Press, Inc. p. 79. ISBN 0976748975.

[62] Atomic Energy Commission’s Declassification Review of Reports on Human Experiments and the Public Relations and Legal Liability Consequences, presented as evidence during the 1994 ACHRE hearings.

[63] Goliszek, 2003: pp. 136-137

[64] Moreno, 2001: p. 132

[65] LeBaron, Wayne D. (1998). America’s nuclear legacy. Nova Publishers, pp. 109-111. ISBN 978-1-56072-556- 5.

[66] Moss, William; Eckhardt, Roger (1995). “The Human Plutonium Injection Experiments”. Los Alamos Science. Radiation Protection and the Human Radiation Experi¬ ments (23): 177-223. Retrieved 6 December 2013.

[67] , Advisory Committee on Human Radiation Experiments, 1985

[68] Welsome, Eileen (1999). The Plutonium

Files:America ’{/s Secret Medical Experiments in the Cold War. Dial Press. ISBN 0385314027. Retrieved 6 December 2013.

[69] Eileen Welsome (1999). The Plutonium Files: America’s Secret Medical Experiments in the Cold War. New York: Dial Press, pp. 146-148. ISBN 0-385-31402-7.

[70] “Plutonium Files: How the U.S. Secretly Fed Radioactiv¬ ity to Thousands of Americans”, Democracy Now!, May 5, 2004

[71] LeBaron, Wayne D. (1998). America’s nuclear legacy. Nova Publishers, pp. 97-98. ISBN 978-1-56072-556- 5.

[72] Pacchioli, David, (March 1996) “Subjected to Science”, Research/Penn State, Vol. 17, no. 1

[73] Goliszek, 2003: p. 139

[74] “America’s Deep, Dark Secret”. CBS News. April 29, 2004. Retrieved February 18, 2010.

[75] Abhilash R. Vaishnav (1994). The Tech online edition. The Tech.

[76] Perni, Holliston (2005). A Heritage of Hypocrisy. Pleas¬ ant Mount Press, Inc. p. 79. ISBN 0976748975.

[77] “Transcript - February 15, 1995”, Eleventh Meeting, February 19-20, 1995 - Washington D.C., Advisory Committee on Human Radiation Experiments (Retrieved February 19, 2010) - see testimony of Honicker

[78] Eckart, 2006: p. 263

[79] Cherbonnier, Alice (October 1, 1997) “Nasal Radium Irradiation of Children Has Health Fallout”, Baltimore Chronicle and Sentinel (Retrieved February 19, 2010)

[80] Danielle Gordon (January 1996). “The Verdict: No harm, no foul”. Bulletin of the Atomic Scientists 52 (1).

[81] Stewart A. Farber (March 12, 1996). “Nasal Radium Ir¬ radiation: Bad Science, Bad Medicine, Bad Ethics”. Tes¬ timony to U.S. Senate Committee on Governmental Affairs (ACHRE hearings).

[82] Skloot, Rebecca (2010, 2011). The Immortal Life of Hen¬ rietta Lacks. New York: Broadway Paperbacks, p. 33. ISBN 978-1-4000-5218-9. Check date values in: ldate= (help)

[83] Goliszek, 2003: p. 253

[84] LeBaron, Wayne D. (1998). America’s nuclear legacy. Nova Publishers, p. 105. ISBN 978-1-56072-556-5.

[85] Goliszek, 2003: pp. 223-225

[86] Institute of Medicine (U.S.). Committee on Thyroid Screening Related to 1-131 Exposure, National Research Council (U.S.). Committee on Exposure of the American People to 1-131 from the Nevada Atomic Bomb Tests, ed. (1999). Exposure of the American people to Iodine-131 from Nevada nuclear-bomb tests: review of the National Cancer Institute report and public health implications. Na¬ tional Academies Press. pp. 113-114. ISBN 978-0-309- 06175-9. - deaths taken from 90% survival rate, applied to # of cases

[87] ACHRE Report:New Ethical Questions for Medical Re¬ searchers

“In 1949, the AEC undertook Project GABRIEL, a se¬ cret effort to study the question of whether the tests could threaten the viability of life on earth. In 1953, Gabriel led to Project Sunshine...”

[88] U.S. Department of Energy, “Report on Project Gabriel”, July 1954

[89] Goncalves, Eddie (June 3, 2001). “Britain snatched ba¬ bies’ bodies for nuclear labs”. The Guardian (London).

[90] “REPORT ON PROJECT GABRIEL”. U.S. ATOMIC ENERGY COMMISSION Division of Biology and Medicine. Retrieved 2013-09-26.

[91] “Dundee University Medical School; PDF” (PDF). Re¬ trieved 2012-12-16.

[92] LeBaron, Wayne D. (1998). America’s nuclear legacy. Nova Publishers, pp. 99-100. ISBN 978-1-56072-556- 5.

[93] Thomas H. Maugh II, “Eugene Saenger, 90; physician conducted pivotal studies on effects of radiation expo¬ sure”, Los Angeles Times, October 6, 2007 (Retrieved February 18, 2010)

[94] “Human Experiments”. Netti.fi. Retrieved 2012-12-16.

[95] Cockburn, Alexander; Jeffrey St. Clair (1998). Whiteout: The CIA, Drugs and the Press. New York: Verso, pp. 157-159. ISBN 1-85984-258-5.

[96] Goliszek, 2003: Ch. 4

[97] Moreno, 2001: pp. 40-43

[98] Freeman. Karen (December 1991). “The Unfought Chemical War”. Bulletin of the Atomic Scientists: 30-39.

16

10 REFERENCES

[99] Pechura, Constance M. & Rail, David P., ed. (1993). Veterans at Risk: the health effects of mustard gas and Lewisite. National Academies Press, p. 31. ISBN 978-0- 309-04832-3.

[100] Cina & Perper, 2010: p. 96

[101] Mangold, Tom; Goldberg, Jeff (2000). Plague wars: a true story of biological warfare. Macmillan, p. 37. ISBN 978-0-312-20353-5.

[102] B.M. Ansell, F. Antonini, L.E. Glynn: “Cantharides blis¬ ters in children with rheumatic fever”. Clinical Science, November 1953, 12 (4): 367-373.

[103] Homblum, 1998: p. 216

[104] Cina & Perper, 2010: pp. 92-93

[105] Washington, 2008: pp. 249-262

[106] Kaye, Jonathan. “Retin-A’s Wrinkled Past”, Pennsylvania History Review, Spring 1997.

[107] Hornblum, 1998: p. 320

[108] “Ex-Inmates Sue Penn and Kligman over Research”. The Pennsylvania Gazette (The University of Pennsylvania). January-February 2001. Retrieved November 9, 2009.

[109] Homblum, 2007: p. 52

[110] Goliszek, 2003: p. 226

[111] Goliszek, 2003: pp. 152-154

[112] Michael Evans. “Science, Technology and the CIA”. Gwu.edu. Retrieved 2012-12-16.

[113] Church Committee ; p. 390 “MKULTRA was approved by the DCI [Director of Central Intelligence] on April 13, 1953”

[114] Estabrooks, G.H. “Hypnosis comes of age”. Science Di¬ gest, 44-50, April 1971

[115] Gillmor, D. ISwear by Apollo: Dr. Ewen Cameron and the CIA-Brainwashing Experiments. Montreal: Eden press, 1987.

[116] Scheflin, A.W., & Opton, E.M. The Mind Manipulators. New York: Paddington Press, 1978.

[117] Thomas, G. Journey into Madness: The Secret Story of Se¬ cret CIA Mind Control and Medical Abuse. New York: Bantam, 1989 (paperback 1990).

[118] Weinstein, H. Psychiatry and the CIA: Victims of Mind Control. Washington, DC: American Psychiatric Press, 1990.

[119] Otterman, 2007: p. 23

[120] Otterman, 2007: pp. 21-22

[121] John S. Friedman, ed. (2005). The Secret Histories: Hidden Truths that Challenged the Past and Changed the World. Macm ill an, p. 146. ISBN 978-0-312-42517-3.

[122] Cole, 1996: pp. 31-32

[123] McCoy, 2006: pp. 28-30

[124] Goliszek, 2003: p. 155

[125] APPENDIX C: Documents Referring To Subprojects - 1977 Senate MKULTRA Hearing (Retrieved February 18, 2010)

[126] Otterman, 2007: pp. 24-25

[127] Cockburn, Alexander; Jeffrey St. Clair (1998). Whiteout: The CIA, Drugs and the Press. New York: Verso, pp. 206-209. ISBN 1-85984-258-5.

[128] Otterman, 2007: pp. 45-47

[129] Naomi Klein (2007). “1”. The Shock Doctrine: The Rise of Disaster Capitalism. New York: Metropolitan Books. ISBN 0-8050-7983-1.

[130] Goliszek. 2003: pp. 170-171

[131] Marks, John D„ Chapter 8, The Search for the Manchurian Candidate

[132] Otterman, 2007: p. 27

[133] McCoy, 2006: pp. 50-53

[ 134] Alfred W. McCoy, “U.S. Has a History of Using Torture”, Z Magazine

[135] “Final report of the Select Committee to Study Govern¬ mental Operations with Respect to Intelligence Activi¬ ties, United States Senate : together with additional, sup¬ plemental, and separate views”. Archive.org. Retrieved 2012-12-16.

[136] Gillmor. D. I Swear by Apollo. Dr. Ewen Cameron and the CIA-Brainwashing Experiments. Montreal: Eden Press, 1987.

[137] Scheflin, A.W., & Opton, E.M. The Mind Manipulators, New York: Paddington Press, 1978.

[138] Thomas, G. Journey into Madness. The Secret Story of Secret CIA Mind Control and Medical Abuse, New York: Bantam, 1989 (paperback 1990).

[139] Weinstein, H. Psychiatry and the CIA: Victims of Mind Control, Washington, DC: American Psychiatric Press, 1990.

[ 140] Septal stimulation for the initiation of heterosexual behav¬ ior in a homosexual male. Journal of Behavior Therapy and Experimental Psychiatry Volume 3, Issue 1. (March 1972) Pages 23-26,INI,27-30 Charles E. Moan, Robert G. Heath

[141] Mohr, Clarence L.; Joseph E. Gordon (2001). Tulane: the emergence of a modern university, 1945-1980. LSU Press, p. 123. ISBN 978-0-8071-2553-3.

[142] Baumeister, Alan A. (2000). “The Tulane Electrical Brain Stimulation Program. A historical Case Study in Medical Ethics”. Journal of the History of the Neurosciences 9 (3): 262-278. doi:10.1076/jhin.9.3.262.1787.

[143] Sheldon Richman (June 23, 2010). “Did the CIA Conduct Medical Experiments on Detainees?". Counterpunch.

10.2

Bibliography

17

[144] Experiments in Torture: Human Subject Research and Experimentation in the “Enhanced” Interrogation Pro¬ gram, Physicians for Human Rights, June 2010

See also:

*Related Publications

*Outside Academic Experts Respond to Experiments in Torture

*Complaint to Office of Human Research Protections Re¬ garding Evidence of CIA Violations of Common Rule *Experiments in Torture (video)

[145] Experiments in Torture: Medical Group Accuses CIA of Carrying Out Illegal Human Experimentation, Democracy Now!, June 8, 2010

[146] Accounting for Torture: Being Faithful to our Val¬ ues, (video) National Religious Campaign Against Torture (cited by PHR)

[147] Risen, James (June 6, 2010). “Medical Ethics Lapses Cited in Interrogations”. The New York Times.

[148] ICRC Report on the Treatment of Fourteen “High Value De¬ tainees” in CIA Custody, International Committee of the Red Cross, February 14. 2007

[149] United States Senate Select Committee on Intelligence. “The Senate Committee’s Report on the C.I.A.’s Use of Torture” December 9, 2014.

[150] “Statement of APA Board of Directors: Outside Counsel to Conduct Independent Review of Allegations of Sup¬ port for Torture”. American Psychological Association. 12 Nov 2014.

[151] “California Jail to Test Ray Gun on Prisoners”. Democracy Now!. August 23, 2010.

[152] Weinberger, Sharon (August 30. 2007). “No Pain Ray for Iraq”. Wired. Archived from the original on December 10, 2008. Retrieved December 13, 2008.

[153] “Theory improved treatment and understanding of stut¬ tering:" Ethics concerns led researchers to conceal the ex¬ periment Decades later, the experiment’s victims struggle to make sense of their past, Jim Dyer, San Jose Mercury News, Monday, June 11, 2001 (Retrieved February 17, 2010)

[154] Loue, 2000: p. 30

[155] Elliott, Carl (September/October 2010). “The deadly corruption of clinical trials.” Mother Jones: http://www.motherjones.com/environment/2010/09/ dan-markingson-drug-trial-as trazeneca?page=l

[156] http://markingson.blogspot.com/

[157] http://www.scribd.com/doc/49659724/

U- of- M- Board-of-Regents- Markingson- Letter

[158] Washington, 2008: pp. 60-63

[159] Savitt, Todd Lee (2002). Medicine and Slavery: The Dis¬ eases and Health Care of Blacks in Antebellum Virginia. University of Illinois Press, p. 299. ISBN 978-0-252- 00874-0.

[160] Shamoo & Resnick, 2009: p. 239

[161] Albarelli Jr., H.P.; Kaye, Jeffrey S.; “The Hidden Tragedy of the CIA’s Experiments on Children”, Truthout, Wednesday August 11, 2010

[162] Whitaker, Robert (2010). Mad in America: Bad Science, Bad Medicine, and the Enduring Mistreatment of the Men¬ tally 111. Basic Books, p. 315. ISBN 978-0-465-02014-0.

[163] Cina & Perper, 2010: p. 92

[164] Hornblum, 1999: p. 80

[165] Dober, Gregory “Cheaper than Chimpanzees: Expanding the Use of Prisoners in Medical Experiments”, Prison Le¬ gal News, VOL. 19 No. 3, March 2008

[166] Goldzieher JW, Moses LE, Averkin E, Scheel C, Taber BZ. “A placebo-controlled double-blind crossover investi¬ gation of the side effects attributed to oral contraceptives”, Fertil Steril. 1971 Sep;22(9):609-23. “PMID4105854”

[167] Levine, Robert J. “Ethics and regulation of clinical re¬ search, 2nd ed”. Yale University Press, 1986, p.71-72. ISBN Special:BookSources/0806711124

[168] Veatch RM. “Experimental pregnancy: the ethical com¬ plexities of experimentation with oral contraceptives”. Hastings Cent Rep. 1971 Jun; (l):2-3. “PMID4137658”

[169] Brian Ross (May 23, 2007). “Test of Controversial Arti¬ ficial Blood Product a Failure”. ABC News, “The Blotter”.

[170] Ed Edelson (April 28. 2008). “Experimental Blood Sub¬ stitutes Unsafe, Study Finds”. ABC News.

[171] Bernard, Larry. “Historian examines U.S. ethics in Nuremberg Medical Trial tactics.” Cornell Chronicle

[172] Weindling. Paul (Spring 2001). “The Origins of Informed Consent - Nuremberg Code”, Bulletin of the History of Medicine

[173] Science, Technology, and the CIA, National Security Archive Electronic Briefing Book, Jeffrey T. Richelson, Editor, September 10, 2001 (Retrieved February 18, 2010)

[174] “U.S. Senate: Joint Hearing before The Select Committee on Intelligence and The Subcommittee on Health and Sci¬ entific Research of the Committee on Human Resources”, 95th Cong., 1st Sess. August 3, 1977.

[175] “Final report of ACHRE”. Eh.doe.gov. Retrieved 2012- 12-16.

[176] Henry N. Pontell, Gilbert Geis, ed. (2007). International Handbook of White-Collar and Corporate Crime. Springer, p. 62. ISBN 978-0-387-34110-1.

10.2 Bibliography

• Annas, George J.; Grodin, Michael A. (1995). The Nazi Doctors and the Nuremberg Code: human rights in human experimentation. Oxford University Press. ISBN 978-0-19-510106-5.

18

11 FURTHER RESOURCES

• Brody, Baruch A. (1998). The Ethics of Biomedi¬ cal Research: An international perspective. Oxford University Press. ISBN 978-0-19-509007-9.

• Cina, Stephen J.; Perper, Joshua A. (2010). When Doctors Kill. Springer. ISBN 978-1-4419-1368-5.

• Cole, Leonard A. (1996). The Eleventh Plague: The Politics of Biological and Chemical Warfare. MacMillan. ISBN 978-0-8050-7214-3.

• Eckart, Wolfgang Uwe (2006). Man, Medicine, and the State: The human body as an object of govern¬ ment sponsored medical research in the 20th century. Franz Steiner Verlag. ISBN 978-3-515-08794-0.

• Goliszek, Andrew (2003). In The Name of Science. New York: St. Martin’s Press. ISBN 978-0-312- 30356-3.

• Grodin, Michael A. & Glantz, Leonard H., ed. (1994). Children as Research Subjects: Science, ethics, and law. Oxford University Press US. ISBN 978-0-19-507103-0.

• Halpern, Sydney A. (2006). Lesser Harms: The Morality of Risk in Medical Research. University of Chicago Press. ISBN 978-0-226-31452-5.

• Hornblum, Allen M. (1998). Acres of Skin: Hu¬ man experiments at Holmesburg Prison, a story of abuse and exploitation in the name of medical sci¬ ence. Routledge. ISBN 978-0-415-91990-6.

• Hornblum, Allen M. (2007). Sentenced to Science: One Black Man's Story of Imprisonment in America. The Pennsylvania State University Press. ISBN 978- 0-271-03336-5.

• Lederer, Susan E. (1997). Subjected to Science: Hu¬ man Experimentation in America Before the Second World War. JHU Press. ISBN 978-0-8018-5709-6.

• Loue, Sana (2000). Textbook of research ethics: theory and practice. Springer. ISBN 978-0-306- 46448-5.

• McCoy, Alfred W. (2006). A question of torture: CIA Interrogation, From the Cold War to the War on Terror. New York: Metropolitan Books. ISBN 978- 0-8050-8041-4.

• Moreno, Jonathan D. (2001). Undue Risk: Secret State Experiments on Humans. Routledge. ISBN 0- 415-92835-4.

• Otterman, Michael (2007). American torture: from the Cold War to Abu Ghraib and beyond. Melbourne Univ. Publishing. ISBN 978-0-522-85333-9.

• David J. Rothman (1992). Strangers at the Bedside: A History of How Law and Bioethics Transformed Medical Decision Making. Basic Books. ISBN 978- 0-465-08210-0.

• Shamoo, Adil E.; Resnik, David B. (2009). Respon¬ sible Conduct of Research. Oxford University Press US. ISBN 978-0-19-536824-6.

• Washington, Harriet A. (2008). Medical Apartheid: The Dark History of Medical Experimentation on Black Americans from Colonial Times to the Present. Random House. ISBN 978-0-7679-1547-2.

11 Further resources

11.1 General

• “Human Research Report” - a monthly newsletter on protecting human subjects

• Frankel, MarkS. (1975). “The Development of Pol¬ icy Guidelines Governing Human Experimentation in the United States”. Ethics in Science and Medicine

2 .

• Hornblum, Allen M.; Newman, Judith Lynn; Dober, Gregory J. (2013). Against Their Will: The Se¬ cret History of Medical Experimentation on Children in Cold War America. New York, NY: Palgrave Macmillan. ISBN 978-0-230-34171-5.

• Jonsen, Albert R. (1998). The Birth of Bioethics. Oxford University Press.

• Kalechofsky, Roberta. Human Experimentation: Before the Nazi Era and After.

• Weyers, Wolfgang (2003). The Abuse of Man: An illustrated history of dubious medical experimenta¬ tion. Ardor Scribendi. ISBN 978-1-893357-21-1.

11.2 Biological warfare and dis¬ ease/pathogen experiments

• Bibliography of Chemical and Biological Warfare documents

• The History of Bioterrorism in America, Richard Sanders, Race and History , Sunday, November 24, 2002 (Retrieved February 18, 2010)

• Biological Weapons - Federation of American Sci¬ entists

• Franz, et al.. The U.S. Biological Warfare and Bio¬ logical Defense Programs

• US Army Activities in the US Biological Warfare Pro¬ gram, 1977 Congressional report

• Christopher et al., “Biological warfare. A historical perspective”. Journal of the American Medical As¬ sociation. 6 August 1997;278(5):412-7.

11.4 Psychological/torture/interrogation experiments

19

• Years Ago, The Military Sprayed Germs on U.S. Cities", Wall Street Journal, October 22, 2001, via American Patriot Friends Network. Retrieved November 13, 2008.

11.4 Psychological/torture/interrogation experiments

• Bibliography of U.S. interrogation/torture research

• http://stlouis.cbslocal.com/2012/09/24/ * Truth ’ torture, and the American way, Jennifer Har-

researcher-poor-st-louis-minorities-targeted-for-secfeiRiold-war-chemical-testing/

11.3 Human radiation experiments

11.3.1 Books

• Killing Our Own: The disaster of America’s experi¬ ence with atomic radiation, by Harvey Wasserman, Delacorte Press, cl992, ISBN 978-0-440-04567-0

• The Plutonium Files: America 'v Secret Medical Ex¬ periments, by Eileen Welsome, The Dial Press, 1999, ISBN 978-0-385-31402-2

• Biderman, A. Social-Psychological Needs and “In¬ voluntary” Behavior as Illustrated by Compliance in Interrogation, Sociometry, Vol. 23, No. 2 (June, 1960), pp. 120-147

• The CIA: Mind-Bending Disclosures - Time Maga¬ zine, Monday, August 15, 1977 (Retrieved February 18,2010)

• Resources on Drug Experimentation and Related Mind Control Experiments by the U.S. Government

• Khatchadourian, Raffi (December 7, 2012)

“Operation Delirium”, The New Yorker

• The Treatment: The Story of Those Who Died in the Cincinnati Radiation Tests, by Martha Stephens, Duke University Press, c2002, Durham, N.C., ISBN 0-8223-2811-9

• Bravo for the Marshallese: Regaining Control in a Post-Nuclear, Post-Colonial World, by Holly M. Barker, Wadsworth, 2004. ISBN 0-534-61326-8

11.3.2 Government documents

• Advisory Committee on Human Radiation Experi¬ ments (ACHRE) - National Security Archives

• Exposure of the American population to radioac¬ tive fallout from nuclear weapons tests: a review of the CDC-NCI draft report on a feasibility study of the health consequences to the American popula¬ tion from nuclear weapons tests conducted by the United States and other nations. National Research Council (U.S.). Committee to Review the CDC-NCI Feasibility Study of the Health Consequences from Nuclear Weapons Tests, National Academies Press, 2003 ISBN 978-0-309-08713-1

11.5 Video

• MKULTRA Victim Testimony A - 1977 MKUL- TRA Congressional Hearings

• MKULTRA Victim Testimony B - 1977 MKUL¬ TRA Congressional Hearings

• MKULTRA Victim Testimony C - 1977 MKUL¬ TRA Congressional Hearings

• President Clinton apologizes for Human Radiation Experiments

• Complete transcript of Clinton’s apology for Human Radiation Experiments

• Physicians for Human Rights Accuses CIA of Car¬ rying Out Illegal Human Experimentation - video report by Democracy Now!

• The Dark History of Medical Experimentation from the Nazis to Tuskegee to Puerto Rico - video report by Democracy Now!

11.3.3 Journals

• '"A Little Touch of Buchenwald': America’s Secret Radiation Experiments”, Reviews in American His¬ tory - Volume 28, Number 4, December 2000, pp. 601-606

• Chair’s Perspective on the Work of the Advisory Committee on Human Radiation Experiments by Ruth Faden

20

12 TEXT AND IMAGE SOURCES, CONTRIBUTORS, AND LICENSES

12 Text and image sources, contributors, and licenses

12.1 Text

• Unethical human experimentation in the United States Source: http://en.wikipedia.org/wiki/Unethical%20human%

20experimentation%20in%20the%20Umted%20States?oldid=649921103 Contributors: Shii, Edward, Mark Foskey, PaulinSaudi, Andrevan, Bearcat, Alan Liefting, Piotrus, DragonflySixtyseven, Rich Farmbrough, Vsmith, ESkog, Stesmo, Geraldshieldsl 1, Woohookitty, Tabletop, GregorB, Rjwilmsi, Tare, Ground Zero, Klosterdev, Kolbasz, Jrtayloriv, Bgwhite, Wavelength, Witan, Ytrottier, Lusanaherandraton, Chase me ladies, I'm the Cavalry, Arthur Rubin, Rathfelder, Explainer, Tom Morris, SmackBot, C.Fred, Kintetsubuf- falo, Hmains, Eug, Deli nk, Jxm, Muboshgu, DevSolar, Ohconfucius, Calvados, Gobonobo, NYCJosh, PParkerT, RhoOphuichi, Shandris, Gregbard, Slazenger, Cydebot, Anthonyhcole, Jaerik, Maziotis, RedBanner, Sobreira, Uruiamme, Matthew Fennell, Lakmiseiru, Wolf- manSF, Websterwebfoot, AtticusX, QuizzicalBee, Gabel972, Hzoi, Nyttend, Diego Azeta, Dmehring, Gwem, R'n'B, CommonsDelinker, Nono64, Tgeairn, DrKiernan, Metaldev, Apostle 12, Entropy, RVJ, Hugo999, Johnfos, Philip Trueman, Mark vl.O, Thegargantua, Leav, Wykypydya, Krushia, Plutonium27, Calliopejenl, MaynardClark, Lightmouse, Kumioko (renamed), Dodger67, Lavum, Niceguyedc, Parkwells, Socrates2008, B5200, SpikeToronto, V7-sport, Redthoreau, SchreiberBike, Stepheng3, Aronzak, SDY, XLinkBot, Osarius, Ad- dbot, C6541, Melab-1, Fluffernutter, Jarble, Legobot, Luckas-bot, Yobot, Julia W, Yngvadottir, PMLawrence, AnomieBOT, VanishedUser sdu9aya9fasdsopa, Jimll38, Bluerasberry, Materialscientist, Citation bot, Eumolpo, Crimsonmargarine, Hgriggs, LilHelpa, Alexlange, AbigailAbemathy, Boxandice8, Uniwersalista, Paramecium, Pixel Eater, Specrat, FrescoBot, CaptainFugu, Glom2215, Cs32en, Citation bot 1, Dweezle7, Pinethicket, Skyerise, Jcsegenmd, Gellpak, Bluefist, Gegenwind, Aoidh, Mr.98, RjwilmsiBot, J36miles, EmausBot, John of Reading, Mesora54, Dewritech, Saenger, Insipido, German E. Macias, RedSer, Still polaris, AbigailAnderson, Kraligor, Trananhl980, Infinitjest, Packbr, Alpha Quadrant (alt), Wingman417, Rcsprinter 123, Palosirkka, Donner60, Delia Peabody, Peter Karlsen, Lguipontes, Tyretrotter, ClueBot NG, Delawaresky, Rulew, Primergrey, Mesoderm, CopperSquare, Widr, Helpful Pixie Bot, Shannon Garcia, Titodutta, Calabel992, KS Astoria, BG19bot, Greg Vaughan, WikiTryHardDieHard, AnthonyZZZ, NorthamericalOOO, Dartroom, Badon, Stelpa, Cadiomals, Philpill691, Aisteco, Q2stirofechoes, Anbul21, BattyBot, Simeondahl, MassiveHeadTrauma, Ddcm8991, Khazar2, SNAAAAKE!!, MadGuy7023, Rpafitzpatrick, Hmainsbotl, Flashscapes, Joshtaco, Fulldisclosure2012, Epicgenius, RMNixonl972, MDubler, Elizabeth 1848, Clickyhnky, Correctrix, Nelsonsfx, AioftheStorm, Rjesar, Chronopen, VoceTyrannis, Thedeathofusernames, Monkbot, Formerly 98, Bogdan.caprarescu, Vieque, KgLiberty, Loudlibrary, Xpctr8, Junky One Nine, Yairchaim, BUTTPLUGUE, SPELLCHECKER90210, Sebastianhaerlin and Anonymous: 170

12.2 Images

• File :Chloracne-in-herbicide-worker.png Source: http://upload.wikimedia.Org/wikipedia/commons/5/5a/

Chloracne-in-herbicide-worker.png License: Public domain Contributors: OCCUPATIONAL DERMATOSES - CDC/NIOSH Original artist: NIOSH

• File:Flag_of_the_United_States.svg Source: http://upload.wikimedia.Org/wikipedia/en/a/a4/Flag_of_the_United_States.svg License: PD Contributors: ? Original artist: ?

• File:Project_4.1_final_report_cover.png Source: http://upload.wikimedia.Org/wikipedia/commons/0/0b/Project_4.l_final_report_ cover.png License: Public domain Contributors: Source: E.P. Cronkite, V.P. Bond, L.E. Browning, W.H. Chapman, S.H. Cohn, R.A. Conard, C.L. Dunham, R.S. Farr, W.S. Hall, R. Sharp, N.R. Shulman, Study of Response of Human Beings Accidentally Exposed to Signifi¬ cant Fallout Radiation, Operation CASTLE, Project 4.1, Naval Medical Research Institute, Naval Radiological Defense Laboratory, Defense Atomic Support Agency, Oak Ridge National Laboratory, Report #WT-923 (October 1954). Online at http://worf.eh.doe.gov/data/ihp2/ 2776_.pdf. Original artist: United States Department of Energy

• File:Tuskegee_study.jpg Source: http://upload.wikimedia.Org/wikipedia/commons/e/ef/Tuskegee_study.jpg License: Public domain Contributors: This media is available in the holdings of the National Archives and Records Administration, cataloged under the ARC Identifier (National Archives Identifier) 956104. Original artist: Uploaded by Taco325i